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Simple diffusion by
Filipe Faria Berçot; Antonio Augusto Fidalgo Neto and Luiz Anastácio Alves
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Simple diffusion is a kinetic movement of molecules or ions through an opening in the membrane or through intermolecular spaces without any interaction with transporter proteins.

Simple diffusion can occur through two pathways:

1) through the interstices in the lipid bilayer where the substance is soluble in lipids.
2) or via water channels present in the entire length of the membrane.
Passive transport: Simple diffusion
Cellular Physiology